TechnologyHow do neural interfaces work?
How we interface with the nervous system
Every neural interface trades access, resolution and invasiveness against each other. This explorer places 32 of them on one map, by what they do and how far they have come, so that an EEG cap, a deep brain stimulator and an intracortical array can be read on the same terms.
BCI is evolving from decoding the nervous system to interacting with it.
- Reading
- Writing
- Closed loop
- Biohybrid
32 interfaces
Read
Bidirectional
Write
Non-invasive
Around the head
On the skin
Minimally invasive
Vessel or skull window
Invasive
Nerve or sense organ
On the cortex
In the cortex
Deep brain
Biohybrid · Adjacent frontier
Living neural tissue outside the body. Not an interface with a person.
Colour · function
- Read
- Write
- Bidirectional
- Biohybrid
Fill · maturity as a clinical modality
- Established
- Human feasibility
- Early human
- Preclinical
- Research frontier
- Adjacent frontier
ReadMinimally invasiveElectrical
Endovascular interfaces
A stent-mounted electrode array is delivered by catheter through the jugular vein and lodged in a blood vessel beside the motor cortex.
Showing Endovascular interfaces: Read, Minimally invasive.
- Where it acts
- Inside a cerebral blood vessel
- Information flow
- Brain → stent electrodes
How far it has come
- As a clinical modality
- Human feasibilityBuilt on routine neurointerventional procedures. Recording from a vessel is new.
- As a BCI application
- Human feasibilityEarly feasibility studies in people with paralysis, using the system at home.
- Access
- Minimally invasive
- Mechanism
- Electrical
- Target
- Cortex
- Signal
- Field potentials recorded through the vessel wall
Characteristics · read interfaces
- Spatial resolutionCoarse; limited by vessel anatomy
- Temporal resolutionMilliseconds
- Signal richnessField potentials from a few contacts
- CoverageCortex adjacent to the vessel
- InvasivenessCatheter procedure, no craniotomy
- Long-term stabilityStable over 12 months in a first study
Each track runs from low to high. A wide bar means the characteristic varies across implementations.
Strengths
- No open brain surgery
- Uses an established neurointerventional procedure
Trade-offs
- Low channel counts to date
- Placement constrained to where vessels run
Common applications
- Computer control for people with paralysis
Human evidence
Four implanted participants completed 12 months with no serious adverse event, vessel occlusion or device migration, and each controlled a computer (2023). A US study has implanted six more.
What needs to happen next
A pivotal trial, and more channels within the limits of vessel size.
- Used by
- Synchron
- Research
- Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients: The SWITCH StudyMotor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience
- Use cases
- ControlCommunicate
- Patent activity
- 20 patent families name this interface, most often on electrodes and arrays, endovascular access, stimulation. The patent landscape
Descriptions, ranges and maturity levels are editorial analysis, kept qualitative where the literature does not support exact comparison across technologies. Specific devices differ.
All 32 interfaces as a table
| Interface | Function | Access | Mechanism | Target | Clinical modality | BCI application |
|---|---|---|---|---|---|---|
| Read | Non-invasive | Electrical | Cortex | Established | Human feasibility | |
| Read | Non-invasive | Magnetic | Cortex | Established | Research frontier | |
| Read | Non-invasive | Optical | Cortex | Human feasibility | Research frontier | |
| Read | Non-invasive | Electrical | Muscle / neuromotor | Established | Established | |
| Read | Minimally invasive | Electrical | Cortex | Human feasibility | Human feasibility | |
| Read | Minimally invasive | Acoustic | Cortex, Deep brain | Early human | Preclinical | |
| Read | Invasive | Electrical | Peripheral nerve, Muscle / neuromotor | Early human | Early human | |
| Read | Invasive | Electrical | Cortex | Established | Human feasibility | |
| Read | Invasive | Electrical | Cortex | Human feasibility | Human feasibility | |
| Read | Invasive | Electrical | Deep brain, Cortex | Established | Early human | |
| Write | Non-invasive | Magnetic | Cortex | Established | Research frontier | |
| Write | Non-invasive | Electrical | Cortex | Human feasibility | Research frontier | |
| Write | Non-invasive | Acoustic | Cortex, Deep brain | Early human | Research frontier | |
| Write | Invasive | Electrical | Peripheral nerve | Established | Early human | |
| Write | Invasive | Electrical | Retina | Human feasibility | Human feasibility | |
| Write | Invasive | Electrical | Cochlea | Established | Established | |
| Write | Invasive | Electrical | Brainstem | Established | Established | |
| Write | Invasive | Electrical | Cortex | Established | Early human | |
| Write | Invasive | Electrical | Cortex | Early human | Early human | |
| Write | Invasive | Optical, Molecular | Cortex, Deep brain, Retina | Early human | Preclinical | |
| Write | Invasive | Electrical | Deep brain | Established | Early human | |
| Bidirectional | Invasive | Electrical | Peripheral nerve, Muscle / neuromotor | Early human | Early human | |
| Bidirectional | Invasive | Electrical | Cortex | Established | Early human | |
| Bidirectional | Invasive | Electrical | Cortex, Deep brain | Established | Human feasibility | |
| Bidirectional | Invasive | Electrical | Cortex, Spinal cord | Early human | Early human | |
| Bidirectional | Invasive | Electrical | Cortex | Early human | Early human | |
| Bidirectional | Invasive | Electrical | Deep brain, Cortex | Established | Early human | |
| Bidirectional | Invasive | Electrical | Deep brain | Established | Human feasibility | |
| Biohybrid | Ex vivo | Electrical, Biological | Cultured neural tissue | Adjacent frontier | Adjacent frontier | |
| Biohybrid | Ex vivo | Electrical, Optical, Biological | Cultured neural tissue | Adjacent frontier | Adjacent frontier | |
| Biohybrid | Ex vivo | Biological, Electrical | Cultured neural tissue | Adjacent frontier | Adjacent frontier | |
| Biohybrid | Ex vivo | Biological, Electrical | Cultured neural tissue | Adjacent frontier | Adjacent frontier |
Use-case explorer
Start from what people want to do
Nine human goals. Each one connects the technology, the companies, the research, the studies and the tools behind it, and says plainly what is available today.
Decoding attempted speech or writing into text and voice.
Can someone who cannot speak hold a conversation again?
Research participants with paralysis have used implanted BCIs to produce text and synthesised voice from attempted speech. All such systems remain in early feasibility studies.
Latest milestoneA single surface implant decoded speech and upper-body gestures at the same time in three participants.
- Companies
- NeuralinkSynchronPrecision NeuroscienceParadromicsBlackrock NeurotechBrainGateStairMedNeuroXessNeuCyber NeuroTechABILITY NeurotechJiMEDg.tec medical engineeringArayaCognixion
- Research
- Simultaneous speech and gesture decoding for multimodal communication in paralysisAn Accurate and Rapidly Calibrating Speech NeuroprosthesisAn instantaneous voice-synthesis neuroprosthesisA high-performance speech neuroprosthesisA high-performance neuroprosthesis for speech decoding and avatar control+10 more
- Clinical
- VOICEConnect-OneBrainGate2BRAVOUNPCortiCom+3 more
- On the calendar
- BCI Meeting 2027
Why do such different devices exist for the same goal? Each trades signal quality against surgical access. Read the dossier